The life cycle of a mouse makes it easy to see why these rodents are such common pests. It’s not that the mouse lifespan is unnaturally long, but more that mice are notorious breeders. Just one female mouse in your home can average between 25 and 60 offspring in a single year. In the wild, the average lifespan of a mouse tends to be about five or six months. If living in ideal conditions, they can live for approximately two years. Ideal conditions for a mouse mean a steady supply of food without intense competition from other rodents .